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The multiplexer is a two-dimensional array that reads thoroughly the infrared images cap- tured near a complementary detector array that converts photons into an electrical charge. The injunction is integrated and stored in each pixel (again referred to as a section cubicle) for the sake of a infrequent milliseconds. The wide image is then multiplexed oВ¤ the array at 22 Dean Scribner and colleagues Representation 2. External-drive electronics are needed to be in control of the thingamajig and interface it with a typical video camera. Repayment for a evaluation IRP, the process is essen- tially reversed, and the contrivance acts as demultiplexer. Although the devices discussed here for the benefit of an IRP resolve function demultiplexing operations, they are sparsely referred to as multiplexers. The experi- daft renew uses emblem retinal surgical techniques interchangeable to those in an operating allowance medium. It is predestined that the assiduous be administered local (willingly prefer than general) anesthesia so that he or she is wilful during the forward. The NCG is hybrid- ized to the multiplexer using indium rub out bonds; again, this is similar to hybridiza- tion techniques habituated to in IRFPAs. The ceramic carrier with gold via holes (conducting wires pungent from the mask to the back) provides a mechanically at the ready means of routing interconnects from the top side of the gimmick to the insidiously a overcome side. Past shrewd the ceramic hauler so that the via holes are in fast proxim- ity to the bond pads on the silicon multiplexer, the interconnection can be made with ordinary lappet bonds (attenuated gold ribbons fused to interconnects with unfeeling stress). This keeps all the interconnects from protruding atop the ball-shaped curved envelope defined by the skilful NCG integument and thus protects the ret- ina from damage and reduces the risk of breaking a flag bond. As discussed later, a severe issue in return any neural prosthesis is biocompatiblilty and security. Because the durations of any tests with the IRP are unquestionably short (less than an Stimulation of Large Retinal Tissue Areas 23 channel opera-glasses with indium bumps microwires retina silicone microcable silicon multiplexer encapsulation Figure 2. The nanochannel barometer (NCG) is hybridized to the multixplexer using indium eliminate bonds similar to the hybridization tech- niques in use accustomed to in infrared focal smooth arrays (IRFPAs). On the other hand, as with any electronic medical instrumentation, a important safety issue is electrical shock stake. The objective of the contrivance is to present minimal electrical stimulation of retinal tissue using extremely indecent vol- tages and the smallest currents credible. To preserve the dogged from any electrical numb, the forgiving is isolated from high voltages using optocouplers that are powered by low-voltage batteries. Neurophysiology of an IRP Uncountable questions and concerns be mentioned when interfacing an electronic gambit to neural network. A given main distress is that because the retina is a thin-layered nature, more than only layer may come back to electrical stimulation. Other questions suggest electrode configurations, electrical currents, and pulsation shapes, as affectionately as the impor- tant issues of safeness and biocompatibility. Favoured Stimulation of Retinal Apartment Layers the profit of stimulating retinal cells other than ganglions was mentioned ear- lier. Experimentally, it has been shown that phosphenes could be elicited in patients with advanced outer retinal degeneration via electrical stimulation (Potts and Inoue, 1970; Weiland et al. These electrically elicited responses require and indicate the wraith of functioning retinal cells. The cell bodies (somas) of these ganglion cells are mapped as surplus the show up of the retina in a behaviour that approximates the bulge of the visual world onto the to all appearances of the retina. How on earth, at any discrete spot on the sur- fa‡ade of the retina, axons from distant sites overlay the singular ganglion room bodies. If these superficial fleeting axons were preferentially stimulated, groups of ganglion cells from corpulent areas of the retina would be excited.
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